PRODUCTION OF CARBOXYLIC ACID

摘要

PURPOSE:To obtain an corresponding carboxylic acid of high purity without a side reaction by hydrolyzing an unstable carboxylic acid ester such as an amino acid ester or an unsaturated fatty acid ester in the presence of a tertiary amine catalyst under a very high pressure. CONSTITUTION:Especially an unstable carboxylic acid ester such as an amino acid ester or an unsaturated fatty acid ester is hydrolyzed under >=5kbar (preferably 8-100kbar) to obtain a corresponding carboxylic acid of high purity. The above-mentioned hydrolysis is carried out preferably using a tertiary amine catalyst (e.g. triethylamine) in an amount of 1.0-1.5 equivalent based on 1 ester group. The reaction is recommendably carried out at -50 to 50 deg.C by using a mixture solvent between an organic solvent (e.g. acetonitrile or alcohol) and water.