发明名称 |
NANBV DIAGNOSTICS AND VACCINES |
摘要 |
<p>A pharmaceutical composition comprising a hepatitis C virus (HCV) antisense polynucleotide which is selectively hybridizable for the sense strand of the genome of an HCV, wherein the polynucleotide comprises a contiguous sequence of at least 8 nucleotides complementary to the sense strand of the genome of an HCV and a pharmaceutically acceptable excipient, wherein HCV is characterized by: (i) a positive stranded RNA genome; (ii) said genome comprising an open reading frame (ORF) encoding a polyprotein; and (iii) said polyprotein is encoded by an HCV genome wherein the HCV genome has an homology at the polypeptide level of at least 40% to the 169 amino acid sequence shown in Figure 11.</p> |
申请公布号 |
GR910300016(T1) |
申请公布日期 |
1991.11.15 |
申请号 |
GR19910300016T |
申请日期 |
1991.11.15 |
申请人 |
CHIRON CORPORATION |
发明人 |
HOUGHTON, MICHAEL;CHOO, QUI-LIM;KUO, GEORGE |
分类号 |
A61K39/00;A61K31/70;A61K39/29;A61K39/395;A61K48/00;A61P31/12;A61P31/14;C07H21/04;C07K7/06;C07K7/08;C07K14/00;C07K14/02;C07K14/10;C07K14/18;C07K16/00;C07K16/08;C07K16/10;C07K19/00;C12N1/19;C12N5/10;C12N7/00;C12N15/02;C12N15/09;C12N15/40;C12N15/51;C12P21/02;C12P21/08;C12Q1/68;C12Q1/70;C12R1/865;C12R1/91;G01N33/15;G01N33/53;G01N33/531;G01N33/569;G01N33/576;G01N33/577;(IPC1-7):C12N15/51 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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