摘要 |
<p>A process for preparing [1H]-isoindolin-1-one-3-carboxylic acid comprising the steps of 1) reacting phthaladehydic acid in an alkanol with ammonia, 2) contacting the resulting solution with an alkali metal cyanide, 3) removing the alkanol, 4) adjusting the pH to 1.0, 5) heating the resulting reaction mixture until product formation is substantially complete and isolating the product.</p> |