发明名称 |
INHIBITION OF INFLUENZA VIRUS REPLICATION BY OLIGONUCLEOTIDES |
摘要 |
A method of inhibiting influenza virus replication through the activity of natural (unmodified) or modified oligonucleotides (oligodeoxynucleotides or oligoribonucleotides) which hybridize to a selected region of the influenza virus RNA and interfere with its ability to serve as a template for synthesis of encoded products. Oligonucleotides (unmodified or modified) which have antiviral activity against influenza virus as a result of their ability to hybridize to a selected region of influenza virus RNA and inhibit its ability to serve as a template for synthesis of encoded products, as well as compositions which include the oligonucleotides. |
申请公布号 |
WO9116902(A1) |
申请公布日期 |
1991.11.14 |
申请号 |
WO1991US02932 |
申请日期 |
1991.04.29 |
申请人 |
HYBRIDON, INC. |
发明人 |
AGRAWAL, SUDHIR;LEITER, JOSEF, M., E.;PALESE, PETER;ZAMECNIK, PAUL, C. |
分类号 |
A61K31/70;A61K31/7088;A61P31/12;A61P31/16;C07H21/00;C07H21/04;C12N15/113;C12Q1/70 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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