摘要 |
<p>Compounds of the formula <CHEM> and pharmaceutically acceptable salts and tautomeric mixtures thereof possess activity as HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula, Z is <CHEM> R<1> and R<2> are each independently fluoro or hydrogen, except that at least one of R<1> and R<2> is fluoro; R<3> is hydrogen, alkyl, cycloalkyl, aryl or arylalkyl; and R<4> is hydrogen, alkyl, ammonium, alkylammonium, or alkali metal.</p> |