| 摘要 |
PURPOSE:To easily produce the subject compound useful as an intermediate for pharmaceuticals, etc., in one step and high efficiency at a low cost by simultaneously carrying out the hydroxycyanation and the selective acetylation of an aromatic aldehyde by a specific method using a lipase. CONSTITUTION:The objective compound of formula II is produced by carrying out the above reactions in an organic solvent in the presence of (A) lipase, immobilized lipase, lipase-producing microorganism, immobilized product of said microorganism or treated and immobilized product of said microorganism and (B) an aromatic aldehyde of formula I (R<1> to R<3> are H, halogen, etc.; X is O, S, etc.), a cyano group-donative organic cyanogen compound, an acetyl group-donative acetic acid ester and a catalytic amount of an organic base. |
