INHIBITORS OF FACTOR XII ACTIVATION AND APPLICATIONS THEREOF

摘要

2082643 9117258 PCTABS00008 Compositions and methods for prophylactically or therapeutically treating sepsis consisting of an inhibitor of Factor XII activation wherein the inhibitor is preferably antibody and has the exemplary properties: binds to and inactivates Factor XII in plasma; substantially inhibits the enzymatic activity of Factor XIIa; and is substantially unreactive with Factor XII-C1 complexes.