Procedure for obtaining new trioxo-thieno-[2,1] benzothiazepines

摘要

The procedure for obtaining new trioxo-thieno-[2,1] benzothiazepines is characterized by the successive use of three reaction stages which are illustrated in the following diagram: <IMAGE> Stage 1. Reaction between a derived chlorosulphonyl of type (II) and an aniline, which may or may not be substituted, to give the corresponding sulphonamide-ester (III); Stage 2. Hydrolysis of the ester group of the compounds of formula (III) obtained in the preceding stage to the corresponding carboxylic acids of formula (IV); and Stage 3. Intramolecular cyclization of the carboxylic acids (IV) to the final compounds (I). These compounds have a therapeutic application as potential antibacterial, diuretic or antihypertensive agents.