| 摘要 |
PURPOSE:To obtain the subject compound useful as a synthetic intermediate for an antibacterial beta-lactam compound in high yield and stereo-selectivity by using a carboxylic acid derivative as a starting substance, subjecting the component to successive reactions and finally electrolyzing the reaction product. CONSTITUTION:The objective compound of formula VI can be produced by using a compound of formula I (R<3> is protected carboxyl) as a starting substance, reacting with formaldehyde or a substance having equivalent reactivity, reacting the reaction product with a compound of formula II (R<4> is lower alkyl), isomerizing the product to obtain a compound of formula III, reacting with an acid to acylate the primary alcohol and form a compound of formula IV (R<5> is acyl), introducing a hydroxy-protecting group, converting the resultant compound of formula V into a compound of formula R<2>-NH2 (R<2> is lower alkoxy) and electrolyzing the compound after cyclization reaction. |
