SYNTHETIC PIPERIDINEDIONES WITH CYTOSTATIC ACTIVITY

摘要

The present invention are novel compounds of formula (I), wherein R is OH, NH2, OW, or H; X is H, F, Cl, Br, I, OH, OW, NO2 or NH2; Y is H, F, Cl, I, or Br; W is C(O)Z or a C1 to C12 alkyl group; Z is an aliphatic or aromatic group of from C1 to C12; X and Y can both vary within the molecule; and if R is H, at least one of X or Y is not H. In a preferred embodiment, R is OH or NH2. The most preferred compound is (4-hydroxy-3-N-phenylacetylamino-2,6-piperidinedione), in which R is OH, X is H and Y is H. These compounds have cytostatic activity and insert stereochemically into DNA.