发明名称 |
GAS PERMEABLE THROMBO-RESISTANT COATINGS AND METHODS OF MANUFACTURE |
摘要 |
The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a solution of at least one bioactive molecule which counteracts a blood-material incompatibility reaction, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface is capable of resisting blood-material incompatibility reactions while maintaining high gas permeability. |
申请公布号 |
WO9115952(A1) |
申请公布日期 |
1991.10.31 |
申请号 |
WO1991US02415 |
申请日期 |
1991.04.09 |
申请人 |
CARDIOPULMONICS, INC. |
发明人 |
WINTERS, SUZANNE;SOLEN, KENNETH, A.;SANDERS, CLIFTON, G.;MORTENSEN, J., D.;BERRY, GAYLORD |
分类号 |
A61L33/00;A61M1/16;A61M1/36;B01D67/00;B01D69/12;C08G65/32;C08G77/46;C08J7/04;C12N11/06 |
主分类号 |
A61L33/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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