发明名称 |
INHIBITION OF INFLUENZA VIRUS REPLICATION BY OLIGONUCLEOTIDES |
摘要 |
2081777 9116902 PCTABS00008 A method of inhibiting influenza virus replication through the activity of natural (unmodified) or modified oligonucleotides (oligodeoxynucleotides or oligoribonucleotides) which hybridize to a selected region of the influenza virus RNA and interfere with its ability to serve as a template for synthesis of encoded products. Oligonucleotides (unmodified or modified) which have antiviral activity against influenza virus as a result of their ability to hybridize to a selected region of influenza virus RNA and inhibit its ability to serve as a template for synthesis of encoded products, as well as compositions which include the oligonucleotides.
|
申请公布号 |
CA2081777(A1) |
申请公布日期 |
1991.10.31 |
申请号 |
CA19912081777 |
申请日期 |
1991.04.29 |
申请人 |
WORCESTER FOUNDATION FOR EXPERIMENTAL BIOLOGY;MT. SINAI SCHOOL OF MEDICINE |
发明人 |
AGRAWAL, SUDHIR;LEITER, JOSEF M.E.;PALESE, PETER;ZAMECNIK, PAUL C. |
分类号 |
A61K31/70;A61K31/7088;A61P31/12;A61P31/16;C07H21/00;C07H21/04;C12N15/113;C12Q1/70;(IPC1-7):A61K31/70 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|