| 摘要 |
<p>The invention provides a targeted drug release formulation for delivery of drugs to the small intestine and colon af a mammal consisting essentially of a plurality of multidose units each said unit having a particle size of less than about 5mm and consisting essentially of a core of a drug (free of aminosalicylic acid functional groups and excluding anti-inflammatory and antiphlogistic drugs having a local action in the intestine, corticosteroids for the local treatment of chronic intestinal inflammation or irritation, and peppermint oil) surrounded by two membranes, one membrane consisting essentially of a pH dependent polymer which is substantially soluble at a pH greater than about 5.0, and the second of said membranes consisting essentially of one or more polymers such that said second membrane is substantially insoluble in but permeable to gastro-intestinal fluids. Said formulation is characterized by the release of no more than about 10 % drug into the stomach with all of the remainder of the drug being released in the small intestine and/or colon in a period from about 1/2 hour to about 8 hours.</p> |
