Ultrasound contrast agent, vaccine, diagnostic or therapeutic agent

摘要

A pharmaceutical compsn. contains a polyelectrolyte complex in microparticular form and at least one active agent. The active agent is pref. active peptide, protein, enzyme, enzyme inhibitor, antigen, cytostatic, antiinflammatory, antibiotic, vaccine, and optional additives such as adjuvants, amphiphilic molecules etc. The polyelectrolyte pref. contains at least two components including a polymer, e.g. xylan polysulphate, dextran sulphate, polyaminoacd, polysaccharide polysulphate, insulin, hydroxyethyl starch, polysaccharide polysulphonate, polyphosphate, polysaccharide polyphosphate, poly-L-lysine, poly alpha, beta-(2-dimethylamino ethyl)-D,L-aspartamide, chitosan, lysine octadecyl ester, or aminated dextran, cyclodextrin, cellulose ether or pectin and derivs., especially hydrophobised polybase derivs. The polyelectrolyte particles have an average size of up to 5 microns or less than 15 microns or less than 100 microns and are formed by mixing aq. sols. of acidic and basic components.