Benzimidazolinone derivatives.

摘要

Benzimidazolinone derivatives of the general formula (I): <CHEM> wherein R<1>, R<2> and R<3>, which may be the same or different, each is a hydrogen or halogen atom or a lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, hydroxyl, lower alkoxy, aryloxy, acyl, cyano, carboxyl, a lower alkoxycarbonyl, carbamoyl, nitro or nitrogen-containing 5- or 6-membered heterocyclic group; A is an ethylene group which may optionally have at least one branch; R<4> and R<5>, which may be the same or different, each is a lower alkyl group or R<4> and R<5>, together with the adjacent nitrogen atom, represent a pyrrolidinyl, piperidino or a morpholino group provided that when <CHEM> is a piperidino or diethylamino group, at least one of R<1>, R<2> and R<3> is other than a hydrogen atom, or pharmaceutically acceptable salts thereof, methods of producing the same and pharmaceutical compositions containing the same are disclosed. Pharmacologically, the above compounds (I) have pulmonary surfactant secretion promoting activity.