Compounds effective in inducing cell differentiation and process for preparing same
摘要
This invention provides novel side chain homologs of 1 alpha ,25-dihydroxyvitamin D3 which exhibit enhanced and highly selective activity in inducing differentiation of malignant cells. It also provides a general method of synthesis applicable to the preparation of a variety of vitamin D side chain analogs, and a method of treatment of neoplastic diseases which takes advantage of the selective differentiation activity of the new vitamin D homologs.
申请公布号
US5061699(A)
申请公布日期
1991.10.29
申请号
US19890419347
申请日期
1989.10.10
申请人
DELUCA, HECTOR F.;SCHNOES, HEINRICH K.;PERLMAN, KATO L.;KUTNER, ANDRZEJ
发明人
DELUCA, HECTOR F.;SCHNOES, HEINRICH K.;PERLMAN, KATO L.;KUTNER, ANDRZEJ