HUMANIZED CDR-GRAFTED ANTI-ICAM-1 ANTIBODIES, METHODS OF PREPARATION AND USAGE THEREOF

摘要

2081478 9116927 PCTABS00008 The present invention discloses humanized CDR-grafted antibodies which are capable of binding to the intercellular adhesion molecule ICAM-1. These antibodies are useful in treating specific and non-specific inflammation, rhinoviral infection, HIV infection, the dissemination of HIV infected cells, and asthma. In addition, the humanized antibodies disclosed can be useful in methods of diagnosing and localizing sites of inflammation and infection and tumors expressing ICAM-1.