| 摘要 |
The invention relates to azatetracycle compounds of the formula wherein A is NH or a covalent bond, wherein p is 1 or 0, Ar is an aromatic moiety, B is NH or O, and D is the tetracyclic structure or The compounds are useful in the treatment of gastrointestinal motility disorders such as gastroesophageal reflux, non-ulcer dyspepsia, delayed gastric emptying, ileus, irritable bowel syndrome, and the like. The compounds are also useful as 5-HT3 antagonists. The compounds are therefore useful as antiemetics, analgesics, anxiolytics, and exhibit utility in the treatment of substance abuse, schizophrenia, depression, and migraine headaches, presenile and senile dementia (i.e., Alzheimer's disease and senile dementia of the Alzheimer type), and enhancers of intra-nasal absorption of bioactive compounds.
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