发明名称 |
PROCESS FOR PRODUCING CARBAPENEM COMPOUNDS |
摘要 |
<p>Carbapenem compounds of the general formula <CHEM> wherein R is hydrogen or a carboxylic acid protecting group; R<1> is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy and hydroxyalkyl; R<2> and R<3> are each independently hydrogen, lower alkyl, lower alkoxy or lower alkylthio; and Y is (i) an ester group; (ii) a thioester group; (iii) a piperazinyl or pyrrolidinyl derived carbamate group; (iv) a piperazinyl derived amine group; (v) a piperazinyl derived quaternary ammonium group; or (vi) a group comprising a covalent bond; the ester group and the thioester group being bonded to a substituted quinolonyl or naphthyridonyl group; the piperazinyl or pyrrolidinyl derived carbamate group, the piperazinyl derived amine group and the piperazinyl derived quaternary ammonium group containing a piperazinyl nucleus or a pyrrolidinyl nucleus having a nitrogen atom bonded directly to a substituted quinolonyl or naphthyridonyl group, the piperazinyl and the pyrrolidinyl nuclei being unsubstituted or substituted with one or more lower alkyl groups; and the covalent bond of the corresponding group being connected to a substituted isothiazolo or isoxazolo quinolonyl or naphthyridonyl group via a nitrogen atom in an isothiazolo or isoxazolo nucleus; as well as the corresponding readily hydrolyzable esters, pharmaceutically acceptable salts and hydrates of any of the foregoing compounds. The products have antibacterial activity.</p> |
申请公布号 |
HU911132(D0) |
申请公布日期 |
1991.10.28 |
申请号 |
HU19910001132 |
申请日期 |
1991.04.08 |
申请人 |
F. HOFFMANN-LA ROCHE AG.,CH |
发明人 |
DAX,SCOTT LOUIS,US;KEITH,DENNIS DALTON,US;ROSSMAN,PAMELA LOREEN,US |
分类号 |
A61K31/40;A61K31/397;A61P31/04;C07D477/00;C07D477/14;C07D477/26;C07D519/00 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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