| 摘要 |
Novel 12- and 13-bromoergoline derivatives of the formula <IMG> (I) wherein R is hydrogen or C1-2-alkanoyl, R1 is hydrogen, bromine, or C1-2-alkylthio, wherein at least one of R and R1 is H, and when Br is in the 12-position, R1 is H, and when R1 is bromine C2<IMG>C3 is a double bond, R2 is lower alkyl, R3 is NH-CO-NEt2 or NH-CS-NEt2, C9<IMG>C10 and C2<IMG>C3 each independently is a CCsingle or a C=C-double bond, and the hydrogen atom in the 10position is in the .alpha.-configuration if C9<IMG>C10 is a CC-single bond, and the hydrogen atom in the 3-position is in the .alpha.configuration or .beta.-configuration if C2<IMG>C3 is a CC-single bond, or a pharmaceutically acceptable acid addition salt thereof are suitable as medicines for treating psychic disorders of the depressive array of symptoms and also as intermediates.
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