发明名称 TREATING AGENT FOR BLOOD CELL
摘要 PURPOSE:To obtain an atoxic and useful substance free from elution by immobilizing glucuronic acid to the surface of insoluble carrier by amide bond. CONSTITUTION:An aromatic vinyl-based copolymer including a homopolymer of styrene or alpha-methylstyrene is molded into a molded article such as a laboratory dish, bottle, film, fiber, hollow fiber, granule, etc. Aminomethyl group is introduced to the surface of the molded article to give a light transmitting insoluble carrier (A) having <=3 absorbance at 500-70nm wavelength in >=100mu thickness. Then the component A is immersed in a mixed solution of glucuronic acid and carbodiimide and immobilized to produce a treating agent (B) of blood cell. Optionally the component B is cultured while bringing the component B into contact with leukocyte to produce a cytokinin which is an interleukin such as interleukin-1 and a colony stimulating factor such as GM-CFS.
申请公布号 JPH03236790(A) 申请公布日期 1991.10.22
申请号 JP19900031378 申请日期 1990.02.14
申请人 BIO MATERIAL KENKYUSHO:KK 发明人 TERAMOTO KAZUO;OGAWA YASUKI;NAKAMURA NORIKO;SUDO TETSUHISA
分类号 C12M1/22;A61K35/14;A61M5/14;A61M5/178;A61M25/00;C07H7/033;C12M1/24;C12N11/08;C12P21/00;C12R1/91 主分类号 C12M1/22
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