NEUE CARBACYCLINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL.

摘要

Cpds. of formula (I) and their salts are new, (where R1 is H, OR2 or NHR3, where R2 is H, alkyl, cycloalkyl, aryl, aroylmethyl or a heterocyclic gp., and R3 is R2 or an acid residue; n=2-5; X is H or F; A is CH2CH2, trans-CH=CH2 or CC; W is a free or functionally modified CHOH or CMeOH gp. with the OH gp. in the alpha or beta posn.; D is an opt. F-substd. 1-5C alkylene or unsatd. 2-5C alkylene gp. or -Q-CH2-, where Q is 3-6C cyclo-alkylidene; E is a bond or a CC or CR6=CR7 gp., where one of R6 and R7 is H and the other is 1-5C alkyl or halogen; R4 is alkyl, cycloalkyl, opt. substd. aryl or a heterocyclic gp.; R5 is a free or functionally modified OH gp.). (I) are hypotensives and bronchodilators and also have vasodilatory activity, inhibit thrombocyte aggregation and inhibit gastric acid secretion. Compared with PGE2 and PGA2, they give greater and long-lasting redns. in blood pressure without causing diarrhoea or cardiac arrhythmia.