POLYPEPTIDES WITH A DOPAMINERGIC RECEPTOR ACTIVITY, NUCLEIC ACIDS CODING FOR THESE POLYPEPTIDES AND USE OF THESE POLYPEPTIDES TO SCREEN ACTIVE SUBSTANCES ON THESE POLYPEPTIDES

摘要

The invention relates to new polypeptides with a dopaminergic receptor activity which contain the sequence of 446 amino acids of Figure 1 or a fragment of this sequence, this fragment being such that it nevertheless contains the sites contained in this sequence and whose presence is necessary so that, when this fragment is exposed on the surface of a cell, it is capable of binding the dopamine to its agonists or antagonists in a specific and measurable manner, for example by means of a radioactive ligand; or it is capable of being recognized by antibodies which also recognize the above-mentioned sequence of 446 amino acids but do not recognize either the dopaminergic receptor D-1 or the dopaminergic receptor D-2; or it is capable of generating antibodies which recognize said sequence of 446 amino acids but do not recognize either the dopaminergic receptor D-1 or the dopaminergic receptor D-2.