PURIFIED RAP GAPs, RAP GAP SEQUENCES, AND USES THEREOF

摘要

This invention presents substantially purified rap GAPs (ras proximate guanine triphosphatase activating proteins); and methods for purifying the proteins using either successive chromatographic steps or monoclonal antibodies to the proteins or to the partial amino acid sequences of the protein. The DNA and predicted amino acid sequences of a rap GAP are presented, as well as antibodies against rap GAP and methods for producing such antibodies. Also presented are methods for identifying anti-cancer therapeutics using these rap GAPs.