The invention refers to recombinant DNA plasmid vector containing cDNA encoding human EPO of clone lambda HEPOFL13 (ATCC 40153) and mammalian cell transformed with this vector or with a plasmid which contains the entire bovine papilloma virus DNA and the cDNA sequence of Table 3 coding for human EPO are which useful in the preparation of recombinant human erythropoietin which is characterized by the presence of O-linked glycosilation.
申请公布号
DE411678(T1)
申请公布日期
1991.10.17
申请号
DE19900118215T
申请日期
1985.12.03
申请人
GENETICS INSTITUTE, INC., CAMBRIDGE, MASS., US
发明人
FRITSCH, EDWARD, CONCORD, MASSACHUSETTS 01742, US;JACOBS, KENNETH, NEWTON, MASSACHUSETTS 02160, US;HEWICK, RODNEY M., LEXINGTON, MASSACHUSETTS 02173, US