| 摘要 |
<p>The present invention provides a modulator agent sensitizing tumoral cells to anticancerous drugs and/or inhibiting the tumoral cells resistance to antitumoral drugs, characterized in that it consists in a vinca alkaloid dimer, analog to vinblastine or vincristine, with a low cytotoxicity or devoid of cytotoxicity, comprising at least one stereoisomerism different from that of vinblastine or vincristine in the C-14', C-16' or C-20' position. Notably a modulator agent may have the R absolute configuration in the C-16' position.</p> |
