CARBO-NUCLEOSIDE DERIVATIVES

摘要

A carbo-nucleoside derivative characterised in that it corresponds to general formula (I) wherein ------- represents optional unsaturation; A represents H or sustituent which is F or OH; B represents H or a substituent which is F; Y1 represents H or a physiologically-acceptable group corresponding to the formula: R1(O)nCO(OCR2R3)m- wherein n represents 0 or 1; m represents 0 or 1; R1 represents an optionally unsaturated and/or optionally substituted alkyl, alkyloxyalkyl or aryl group or an N-(C¿1?-C7 alkyl)-1,4-dihydropyridin-3-yl group or, when n represents O, H; R?2 and R3¿ independently represents H, C¿1?-C6 alkyl C2-C6 alkenyl or alkynyl or aryl; alternatively, two of such substituents may be replaced by an alkylidene group; and X represents a group selected from (A), (B), (C), (D), (E), (F), (G), (H), (I), (J) wherein Y?2, Y3 and Y4¿ independently have the same definition as Y1; R4 represents H or -NY?3Y4, Y3 and Y4¿ being as defined above; and R5 represents H or halogen, C¿1?-C6 alkyl, C2-C6 alkenyl or alkynyl or trifluoromethyl; provided that at least one of Y?1, Y2, Y3 and Y4¿ represents other than H and that, when all of Y?2, Y3 and Y4¿ present represent H, then Y1 represents R1(O)nCO(OCR2R3)m wherein n and/or m represents 1; and/or salts thereof is disclosed.