| 摘要 |
<p>A method is disclosed whereby macromolecular chain polymers can be selectively and covalently coupled to other organic molecular entities to provide conjugate compounds using a reaction between a thiol-specific reactive disulphide group, preferably a sulphenyl thiocarbonate group, in one of the molecular species and a sulphydryl or thiol group in the other molecular species. The method is particularly applicable to the selective coupling of bioactive molecules to polymers that can serve as relatively inert carriers in biological systems, for use for example as drug delivery agents containing site-specific targeting moieties. The method further enables inter alia a 1:1 coupling to be achieved between polymeric drug carriers and proteins or polypeptides, including antibodies or antibody fragments.</p> |
