发明名称 |
ALDEHYDE INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF OPTICALLY ACTIVE 3-DE-METHYLMEVALONIC ACID DERIVATIVES |
摘要 |
A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I <IMAGE> I (3,5-dihydroxy carboxylic acid derivatives) or of the formula II <IMAGE> II ( beta -hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII <IMAGE> XII in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host. |
申请公布号 |
AU8141591(A) |
申请公布日期 |
1991.10.17 |
申请号 |
AU19910081415 |
申请日期 |
1991.07.29 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
GUNTHER WESS;KURT KESSELER;EKKEHARD BAADER;GERHARD BECK |
分类号 |
C07D213/55;C07B31/00;C07B53/00;C07C51/00;C07C51/09;C07C51/367;C07C59/01;C07C59/125;C07C59/42;C07C59/58;C07C67/00;C07C69/63;C07D309/30;C07D319/06;C07D405/06 |
主分类号 |
C07D213/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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