1,2-ETHANEDIOL DERIVATIVE AND ITS SALT

摘要

NEW MATERIAL:The compound of formula I [R<1> is (substituted) heterocyclic group; R<2> is H, lower alkyl or OH-protecting group; R<3> is H or lower alkyl; nXR<4> and R<5> groups are same or different H or lower alkyl; R<6> is (substituted) amino or nitrogen-containing heterocyclic group or ammonio; (n) is 0-6] and its salt. EXAMPLE:2-[2-(N,N-dimethylamino)ethoxy]-1-(benzo[b]thiophen-5-yl)ethanol. USE:It has excellent anti-amnesic action and antihypoxic action and is extremely useful as a cerebral function improver. It is useful not only as a treating agent for the sequela of ischemic cerebral disorder and cerebral apoplexy but also as a therapeutic agent or preventive for amnesia and dementia. PREPARATION:The objective compound of formula I wherein R<2> is H or its salt can be produced e.g. by reacting a compound of formula II with a compound of formula III or its salt.