PROTEIN AND PRODUCTION THEREOF

摘要

A trypsin-like protease-resistant modified P31 protein having hepatitis B virus surface antigen activity and ability to bind polymerized human serum albumin as derived from a hepatitis B virus surface antigen P31 protein by such modification as to render at least one trypsin-like protease sensitive site thereof insensitive can be used as a vaccine for prevention of hepatitis B virus infections and as an antigen for diagnosis of hepatitis B virus infections.