2-SUBSTITUTED ALKYL-3-CARBOXY CARBAPENEMS AS ANTIBIOTICS AND A METHOD OF PRODUCING THEM

摘要

31,291 NOVEL 2-SUBSTITUTED ALKYL-3-CARBOXY CARBAPENEMS AS ANTIBIOTICS AND A METHOD OF PRODUCING THEM The invention relates to new 2-substituted alkyl-3-carboxy carbapenems having the formula: with R1, R2, R3, X and Y defined in the specification as antibiotics and beta lactamase inhibitors produced by a novel Michael addition-elimination reaction of a substituted allyl azetidinone in the reaction shown: with Q defined in the specification.