发明名称 Use of amiloride and other pyrazine derivatives for preventing or treating ocular neovascularization.
摘要 <p>A method and composition for preventing and/or treating ocular (including corneal, iridial, retinal, and choroidal neovascularization) in a patient comprises administration of a compound in the class of pyrazine derivative, e.g. amiloride, or one of its derivatives or congeners or one of their pharmaceutically acceptable salts and/or solvates, to the patient. The pyrazine derivatives can be administered by topical administration to ocular tissues with a suitable carrier such as an artificial tear carrier or a petroleum-based ointment, among others. The pyrazine derivative can also be administered orally, by intravenous administration, or by an intraocular implant.</p>
申请公布号 EP0451130(A2) 申请公布日期 1991.10.09
申请号 EP19910870055 申请日期 1991.04.04
申请人 BALTIMORE BIOTECH, INC. 发明人 GLASER, BERT M.;VARNER, HUGH H.
分类号 A61K31/495;C07D241/30 主分类号 A61K31/495
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