| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1> is lower alkyl, (esterified) carboxyl-lower alkyl or cycloalkyl; R<2> is heterocyclic thiomethyl having 1-4 N or S atoms; R<3> is (esterified) carboxy or carboxylate]. EXAMPLE:Benzhydryl (6S,7S)-7-[(Z)-2-(2-aminothiazol-4-yl)-2- methoxyiminoacetamido]-3-(pyridin-4-ylthiomethyl)isocephem-4-carboxylate. USE:An antimicrobial agent against Gram-positive and Gram-negative bacteria and glucose nonfermentative germs, etc., except Pseudomonas aeruginoa excellent in absorbability in living bodies with a long duration of drug effects and low toxicity. PREPARATION:An amino compound expressed by formula II and a carboxylic acid compound expressed by formula III, etc., are subjected to amide bond- forming reaction. |
