| 摘要 |
NEW MATERIAL:A carbazole compound expressed by the formula (R<1> is acetyl, N<1>-isobutyl-ureido-carbonyl; R<2> is n-bentyl, n-hexyl, n-heptyl or isoheptyl). USE:The compound expressed by the formula has antioxidizing action and is a medicine useful for brain disease, heart disease, lever disease and arteriosclerosis, etc. PREPARATION:Streptomyces cyaneus 2007 SVT1 is used as a producing germ strain and cultured in a culture medium containing various kind of nutrient matters under aerobic conditions to provide the novel compound. As the culture medium, a liquid culture medium is used and as a carbon source, glucose, sucrose, etc., is used and as a nitrogen source, meat extract, oat meal, etc., is used and further as necessary organic and inorganic salt are added to the culture medium. As a defoaming agent, adekanol, etc., is used. Aerobic culture is suitable as the culture method and the culture is especially preferably carried out at pH6-7 and 24-27 deg.C for 4 day. |
