TOPICALLY ACTIVE OCULAR GEM-DIACYLTHIADIAZOLE SULFONAMIDE CARBONIC ANHYDRASE INHIBITORS

摘要

This invention relates to compounds of the following formula useful as a carbonic anhydrase inhibitor: A compound of the formula: <IMAGE> and pharmaceutically acceptable salts thereof wherein X is NR12; R1 is <IMAGE> R2 is <IMAGE> R3 is hydrogen or lower alkyl; R is hydrogen or lower alkyl; each R4 and R5 are independently hydrogen or lower alkyl; each R7 and R8 are independently hydrogen or lower alkyl; R6 is OR10 or NR10R11; R9 is OR13 OR NR11R13; R10, R11 R12, and R13 are independently hydrogen or lower alkyl; and n and m are independently 0-6.