PROCESS FOR THE MANUFACTURE OF 2-DEOXY-D-THREO-PENTOFURANOSIDES, INTERMEDIATES FOR THEIR MANUFACTURE AND THEIR USE

摘要

Disclosed is a process for the manufacture of 2-Deoxy-D-threo-pentofu-ranosides of formula 1 (1) wherein R1 is an alkyl group having 1 to 4 carbon atoms and R7 is a hydroxy protection group by reacting a 2-deoxy-D-erythro-pentofuranoside of formula 2 (2) wherein R1 is an alkyl group having 1 to 4 carbon atoms, R3 is an alkyl-, aryl-, alkylaryl- or aralkyl-sulfonyl group, either unsubstituted or substituted one or more times by halogen atoms, nitro or alkoxy groups, an imidazolesulfonyl or halosulfonyl group, and R4 has the same meaning as R3 or signifies a hydroxy protection group. Furtheron disclosed are a process for the manufacture of 3-substituted 2deoxy-D-erythro-pentofuranosides using these compounds and novel and substituted and unsubstituted 2-deoxy-D-pentofuranosides and their use for the manufacture of 3'-substituted 2'-deoxynucleosides.