| 摘要 |
<p>Heterotetracyclic aromatic compounds having biocidal activity containing two hetero atoms selected from oxygen, sulphur and nitrogen and that are substituted by an aminoalkanol group of the formula (I) ArCH2NHR or a monomethyl or monoethyl ether thereof, the compound of formula (I) including these ethers containing no more than 29 carbon atoms in total, or an ester or a salt thereof; wherein Ar is a fused tetracyclic hetero aromatic ring system of formula (α) in which Z is oxygen, sulphur or a group NR1 wherein R1 is hydrogen, methyl or ethyl and (β) is a bicyclic aromatic ring system comprising a phenyl ring and a 5-membered ring system which contains one heteroatom Z1 selected from oxygen, sulphur or a group NR2 wherein R2 is hydrogen, methyl or ethyl; the tetracyclic ring system being optionally substituted by one or two substituents; and R contains not more than eight carbon atoms and is a group (γ) or (δ) wherein m is 0 or 1; R6 is hydrogen or alkyl optionally substituted by hydroxy; R?7 and R8¿ are the same or different and each is hydrogen or alkyl; R9 is hydrogen, methyl or hydroxymethyl; (ε) is a five- or six-membered saturated carbocyclic ring; R?10, R11 and R12¿ are the same or different and each is hydrogen or methyl; R13 is hydrogen, methyl, hydroxy, or hydroxymethyl; R14 is hydrogen, methyl, hydroxy or hydroxymethyl. Processes for preparing the compounds, intermediates in their preparation, pharmaceutical compositions containing them and their use in medicine are also disclosed.</p> |
