METHODS FOR PROTECTING AGAINST CHEMOTHERAPY-INDUCED HAIR LOSS

摘要

The invention relates to methods for protecting against chemotherapy-induced hair loss, or alopecia. In one aspect, the invention discloses a method for protecting against chemotherapeutic agent induced alopecia by administering to a mammalian subject therapeutically effective amounts of: cytokine release inducing biologic response modifier, therapeutically effective amounts of compound(s) selected from the group consisting of recombinant cytokine IL-1, endotoxin, Lipid A, and monophosphoryl Lipid A, and antioxidants. According to the teaching of the invention, the cytokine release inducing biologic response modifier, compound(s) selected from the group consisting of recombinant cytokine IL-1, endotoxin, Lipid A, monophosphoryl Lipid A and non-toxic antioxidant can be administered parenterally or can be applied topically. In addition the invention relates to use of cytokine release inducing biologic response modifiers, compound(s) selected from the group consisting of recombinant cytokine IL-1, endotoxin, Lipid A, monophosphoryl Lipid A, and antioxidant in the manufacture of medicament packs for use in protecting against chemotherapeutic agent induced alopecia.