| 摘要 |
<p>A compound of formula (I) wherein R is a hydrogen atom or a methyl group, R1 is a hydrogen atom or a negative charge, each of R?2 and R3¿ which may be the same or different, is a hydrogen atom, a lower alkyl group, a formimidoyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, -COOR4, -CON(R?5)R6, -N(R5)R6, -CH¿2COOR4, -CH2N(R5)R6 or -CH¿2?CON(R?5)R6¿ (wherein R4 is a hydrogen atom or a lower alkyl group, each of R?5 and R6¿ which may be the same or different, is a hydrogen atom or a lower alkyl group, or R?5 and R6¿ form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group and a piperidyl group), A is =NR?7, =N(R7)R8¿, -CON(R7)-, -CON(R7)CO-, -CON(R?7)CON(R8¿)-, -N(R7)CO(CH¿2)sN(R?8)-, -N(R7)CO(CH¿2?)sCON(R?8¿)-, -CON(R7)N(R8)- or -N(R7)(CH2)sN(R8)- {wherein each of R?7 and R8¿ which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, -COOR4, -CON(R?5)R6, -N(R5)R6, -CH¿2COOR4, -CH2N(R5)R6 or -CH¿2?CON(R?5)R6¿ (wherein R?4, R5 and R6¿ are as defined above), s is an integer of from 1 to 3}, p is an integer of from 0 to 3, and each of q and r which may be the same or different, is an integer of from 0 to 5, provided that q and r are not simultaneously 0 and q + r « 6; or a pharmaceutically acceptable salt or ester thereof.</p> |
