| 摘要 |
The present invention relates to the process for obtaining biologically mutant forms of the cell growth regulation factor Oncostatin M. The process comprises the deletion, substitution or insertion of amino acids in the amino acid sequence of Oncostatin M. Recombinant DNA, in vitro mutagenesis and heterologous expression techniques can be used to perform these operations. The mutants of Oncostatin M so obtained may be useful in the induction of biological responses to Oncostatin M and, as such, may have various therapeutic uses, including, but not limited to, the treatment of neoplasias.
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