| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1> is H, (substituted) 1-20C alkyl, aralkyl, cycloalkyl, etc.; R<2> is H, aryl or aminoalkyl; R<3> is formula III (R<5> are R<6> are H, halogen, COOH, etc.; (m) is 0-6), cycloalkyl and cycloalkylalkyl, etc., containing O, S or N in the ring] or salts thereof. EXAMPLE:2-Anilino-5,6-dimethyl-1,4-benzoquinone. USE:A medicine and inhibitor against both enzymes of cyclooxygenase (CO) and lipoxygenase (LO) used for treating and relieving allergies or inflammations such as allergic bronchial asthma, dermatosis, chronic rheumarthritis, arthrosteitis and thrombosis in mammals, especially humans. PREPARATION:For example, a 3-(substituted) 5,6-dimethylbenzoquinone expressed by formula II is allowed to react with a substituted amine expressed by formula IV, preferably in the presence of an inert solvent and an oxidizing agent at ambient temperature to afford the compound expressed by formula I. |
