Process and intermediates for the preparation of substituted 6-(3,5,6,7-tetrahydropyrrolo-¬2,1-c ¬1,2,4 -thiadiazol-3-ylidenimino)-7-fluoro-2H-1,4-benzoxazin-3(4H)-ones

摘要

The invention relates a new process for the preparation of substituted 6-(3,5,6,7-tetrahydropyrrolo[2,1-c][1,2,4]-thiadiazol-3-ylidenimino)-7 -fluoro-2H-1,4-benzoxazin-3(4H)-ones of general formula I <CHEM> in which R<1> is C1-C6-alkyl, C2-C6-alkenyl or C3-C6-alkynyl, and R<2> and R<3>, which may be the same or different, are hydrogen or C1-C4-alkyl, which starts from the known a 2-amino-5-fluorophenol of formula II <CHEM> via the new acetanilide of formula IV <CHEM> in which R is hydrogen or chlorine, via the new 5-nitroacetanilide of formula V <CHEM> via the new 5-aminoacetanilide of formula VI <CHEM> via the new 5-isothiocyanatoacetanilide of formula VIII <CHEM> via the known benzoxazinone isothiocyanate of general formula IX <CHEM> and via the known iminothiadiazole of general formula XI <CHEM> t