发明名称 |
HETEROCYCLIC STEROID COMPOUNDS |
摘要 |
The present invention relates to novel substituted 15-oxa-, 15-thia-, and 15-aza-dihydrolanosterols, to pharmaceutical compositions containing such compounds, and to methods of using these compounds to suppress the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), an enzyme which is important in cholesterol biosynthesis. The overall effect of these heterocyclic lanosterol analogs is to decrease cholesterol formation, thereby resulting in lower serum cholesterol levels in mammals, and impaired ergosterol synthesis in fungi. |
申请公布号 |
WO9113903(A1) |
申请公布日期 |
1991.09.19 |
申请号 |
WO1991US01249 |
申请日期 |
1991.03.05 |
申请人 |
THE DU PONT MERCK PHARMACEUTICAL COMPANY |
发明人 |
KO, SOO, S.;TRZASKOS, JAMES, M. |
分类号 |
A01N43/38;A01N43/00;A61K31/56;A61K31/575;A61K31/58;A61P3/06;C07J;C07J73/00 |
主分类号 |
A01N43/38 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|