发明名称 |
Process for purifying recombinant human beta-interferon. |
摘要 |
<p>A process for the chromatographic purification of recombinant human beta -interferon wherein: a) an aqueous solution of recombinant human beta -interferon in unrefined state is contacted with a siliceous solid matrix equilibrated with deionized water and then eluted with appropriated eluant; b) the eluted fractions containing the recombinant human beta -interferon purified according to the stage a) are loaded on a cation exchange resin; thereafter the rhu- beta -interferon adsorbed upon said matrix is eluted with an appropriated eluant. The recombinant human beta -interferon purified in this way is specifically useful as active agent in the production of pharmaceutic preparations suitable for the treatment of viral infections, tumors and as immunomodulators. <IMAGE></p> |
申请公布号 |
EP0446850(A2) |
申请公布日期 |
1991.09.18 |
申请号 |
EP19910103719 |
申请日期 |
1991.03.12 |
申请人 |
SCLAVO S.P.A. |
发明人 |
PROTASI, OTELLO;RAPPUOLI, PAOLO |
分类号 |
A61K38/21;A61P35/00;C07K14/565;C12P21/02;C12R1/91 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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