发明名称 |
CARRIER-BOUND RECOMBINANT PROTEIN, PROCESS FOR PRODUCING IT AND ITS USE AS AN IMMUNOGEN AND VACCINE |
摘要 |
PCT No. PCT/EP91/00308 Sec. 371 Date Sep. 30, 1992 Sec. 102(e) Date Sep. 30, 1992 PCT Filed Feb. 19, 1991 PCT Pub. No. WO91/13155 PCT Pub. Date Sep. 5, 1991.The invention concerns a carrier-bound recombinant protein obtainable by expression of a fusion protein gene in gram-negative bacteria which codes for at least one hydrophobic non-lytically active protein domain capable of membrane integration as well as the recombinant protein and of a gene which codes for a lytically active membrane protein from bacteriophages or a lytically active toxin release gene or lytically active partial sequences thereof and isolation of the carrier-bound recombinant protein from the culture broth. The recombinant protein is thereby firmly incorporated into the cell wall complex of gram-negative bacteria via a target sequence. Furthermore the invention concerns a recombinant DNA for the production of the protein, the production process as well as the use of carrier-bound recombinant proteins according to the present invention for immunization and as vaccines. |
申请公布号 |
AU7237391(A) |
申请公布日期 |
1991.09.18 |
申请号 |
AU19910072373 |
申请日期 |
1991.02.19 |
申请人 |
BOEHRINGER MANNHEIM GMBH |
发明人 |
WERNER LUBITZ;MICHAEL P SZOSTAK |
分类号 |
A61K39/00;A61K39/385;C07K14/00;C07K14/02;C07K14/10;C07K14/155;C07K14/16;C07K14/18;C07K14/36;C07K16/00;C07K16/06;C07K19/00;C12N9/38;C12N15/09;C12N15/62;C12P21/02;C12P21/08;C12R1/19 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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