发明名称 |
PHOSPHOLIPIDPARTIKELN MIT EINGESCHLOSSENEN POLYEN-ANTIBIOTIKA ZUR BEHANDLUNG VON SYSTEMISCHEN PILZINFEKTIONEN. |
摘要 |
Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about .2 (AMB):2(PL): 1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low ionic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections. |
申请公布号 |
AT66597(T) |
申请公布日期 |
1991.09.15 |
申请号 |
AT19870307221T |
申请日期 |
1987.08.14 |
申请人 |
VESTAR, INC. |
发明人 |
ADLER-MOORE, JILL;GAMBLE, RONALD CARL;PROFFITT, RICHARD THOMAS |
分类号 |
A61K9/10;A61K9/127;A61K9/133;A61K31/70;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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