发明名称 |
CEPHALOSPORIN DERIVATIVES WITH IMPROVED PHARMACOKINETICS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT AND SYNTHESIS INTERMEDIATE |
摘要 |
New cephalosporin derivatives of formula: …<IMAGE>… in which:… - each of R1, R2 and R3 denotes a hydrogen atom or each of R1 and R2 denotes a hydrogen atom or a methyl group and R3 denotes a carboxyl group, or R1 and R2 taken together with the carbon atom to which they are linked form a cyclobutyl nucleus and R3 denotes a carboxyl group,… - the 2 groups A are different: one denotes a hydroxyl group and the other denotes a -NH-SO2-Alk-NH2 group in which Alk denotes a C2-C4 lower alkylene group,… and the pharmaceutically acceptable salts and esters of the said derivatives. …<??>The invention also relates to a process for their preparation, pharmaceutical compositions containing them and synthesis intermediates. …<??>The said derivatives exhibit improved pharmacokinetic properties. |
申请公布号 |
AU7945191(A) |
申请公布日期 |
1991.09.12 |
申请号 |
AU19910079451 |
申请日期 |
1991.06.28 |
申请人 |
SANOFI |
发明人 |
BERNARD LABEEUW;ALI SALHI |
分类号 |
C07C311/08;A61K31/545;A61K31/546;A61P31/04;C07C303/38;C07C311/32;C07C311/46;C07D501/04;C07D501/34 |
主分类号 |
C07C311/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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