| 摘要 |
The present invention has multiple aspects. In its first aspect the present invention is directed to a trifunctional antibody-like compound that has tissue, organ, cell or molecule specificity and which is capable of being bifunctional when immobilized, via binding, at the tissue, organ, cell or molecule for which it has specificity. In particular, the present invention is directed to a trifunctional antibody-like compound of Formula I: <CHEM> wherein L is one or two moieties for cross-linking F1ab min , F2ab min and F3ab min ; wherein F1ab min is an Fab min -like fragment of a polyclonal or monoclonal antibody having specificity for an antigen expressed by the organ, tissue, cell or molecule of interest; wherein F2ab min is an Fab min -like fragment of a polyclonal or monoclonal antibody having the same specificity as F1ab min , or having specificity either for a different antigen expressed by the organ, tissue, cell, or molecule of interest, or for a diagnostic or therapeutic agent; and wherein F3ab min is an Fab min -like fragment of a polyclonal or monoclonal antibody having specificity for a diagnostic or therapeutic agent; or wherein F2ab min and F3ab min have specificity for a receptor/receptor complex and accessory molecule on the surface of a T-cell. The compound of the present invention has utility as a pharmaceutical agent. Various methods for treating and diagnosing a disease are also presented. |
