2-Oxoazetidine derivatives and production thereof.

摘要

2-Oxoazetidine derivatives represented by the formula;
wherein R¹ stands for phthalimido group, benzyloxycarbonylamino group, a halogen on an alkyl group which may have hydroxyl group, R² stands for hydrogen, an alkyl group, an alkylthio group or an arylthio group, and R³ and R⁴ independently stand for an acyl group or cyano group, and a method of preparing them, which is shown by the following reaction scheme;
wherein R⁵ stands for a carboxyl-protective group, and R¹, R², R³ and R⁴ are of the same meanings as defined above.

This compound (I) can be utilized as intermediates for carba-2-penem compounds having excellent anti-bactena activity and β-lactamase inhibitory activity.